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DISCUSSIONMolten globule (MG) folding intermediates have been characterized for a number of proteins (for reviews, see Kuwajima, 1989; Ptitsyn, 1992, 1995)
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Recall that, according to the theory, all genes not being expressed--that is, used as a template for making proteins in the cell--should be accumulating mutations and degenerating
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Ultra-violet fluorescence of actin
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Do harshly denaturing environments such as 8 M urea or 6 M GdnCl mimic perfect solvents? In previous work, we developed a fast and accurate way to generate thermal, self-avoiding distributions for proteins with atomistic detail (48)
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The functional form for P(x) in the EV limit has been derived by des Cloizeaux (41) as an interpolation between the predicted results for P(x) for large (87-110) and small x (111)
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CONCLUDING REMARKSGiven the severity of many diseases associated with protein misfolding and aggregation, including the amyloidoses and the transmissible spongiform encephalopathies, research in this area is intense
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The insulin aggregation is promoted under conditions favoring partly destabilized monomers and dimers, such as low pH, high temperature, and contact with hydrophobic media (e
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Another example of this projection is found in the master-equation approach (Zwanzig, 1995), in which the smoothly funneled high-dimensional energy landscape implies some shaping of the nonnative contacts of the underlying model
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Unfolded, yes, but random? Never! Nat
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The gel was broken up by adding Isopar solvent (room temperature, see Figure 3) and stirring the mixture at 6000 rpm for 4 minutes with a Dyna-Mix stirrer (Fisher Scientific, Pittsburgh, PA)
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Toner particle size is very important in xerographic printing for obtaining good optical resolution
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Current models of RNA folding propose distinguishable early and late events during RNA structure formation (Sosnick and Pan, 2003)
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