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. Recently, Zhou (114) computed the functional form of x^sup 2^P(x) from EV simulations of proteins studied by Wilkins et al
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. For lipid T^sub 2^ measurements in the cytoplasm, localized spectroscopy with (200 µm)^sup 3^ voxels was employed with 10 different echo times in intervals of 4 ms, starting at 6
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. 75 ml g^sup -1^ (35) were assumed
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. We also tested the ability of Gα^sub s^ to remain membrane-bound under pressure
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. The exchange broadening must then be due to conformational exchange between different conformations of bound CaM
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. Even though Gα^sub i^(GDP) did not significantly affect the PLCβ^sub 2^-Gβγ equilibrium, it unexpectedly resulted in rapid deactivation of the PLCβ-Gβγ complex when PLCβ activity was monitored (Runnels and Scarlata, 1998)
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. By comparing the volume change of PLCβ-Gβγ alone and in the presence of Gα^sub s^(GDP), we can estimate the volume of activation of PLCβ^sub 2^ by Gβγ-subunits
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. McLeishDepartment of Physics and Astronomy and Astbury Centre for Molecular Biology, University of Leeds, Leeds, United KingdomSubmitted November 4, 2003, and accepted for publication September 7, 2004
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. In this collection of 11 articles, contributors describe their work in PTKs in such areas as using PTKs as targets for cancer and other indications, targeting Src homology 2 domains in drug discovery, using P12-kinase inhibition as a target for therapeutic intervention, using an activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia and JAK kinases in leukemia, lymphomas and multiple myeloma, applying platelet-derived growth factor, using a targeted therapy for myelogenous leukemia, testing signal transduction inhibitors in animal models of cancer, and using phosphoproteomics in drug discovery and development
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