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This key regulator of cellular integrity controls the transcriptional expression of downstream cell cycle regulators, as well as the interactions between the actin cytoskeleton and cadherin within the adherens junctions
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In particular differences in the extent of protein aggregation, in structural compactness, or simply in the structural arrangement of tryptophan residues in unfolded states can change the magnitude of the red shift observed during the unfolding transition significantly
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The newly frozen samples were then allowed to anneal for 12 h at -5°C, followed by a final equilibration of 2 h at the temperature selected for fluorescence measurements (-5 and -13°C)
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The ratio f is usually dominated by the exponential factor, so that the right-hand term in Eq
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3 shows the theoretical RT^sup n^^sub 1^ curves for a molecule with a correlation time, τ^sup o^^sub m^, of 10 ns with one internal motion, τ^sub if^, ranging between 20 ps and 6 ns, and squared order parameter, S^sup 2^^sub f^, ranging between 0
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Thus, the effective size of the monocation in compact DNA is expected to be closer to the size of free ion without hydration shell, where the sequence of the monocation radius is Li+ CONCLUSIONOur investigation highlights the inverse relation between DNA compaction potentials of monovalent cations in a crowded environment and the previously reported DNA binding properties of different alkali ions
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4 acting as lateral scaffolds for formation of following fibrils, which at the same time ensures ordered, parallel organization of large domains of fibrils
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Two sets of atoms were used in the superposition of molecular configurations:1
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Since the docked and undocked peaks are well resolved, any interconversion between the two conformers must occur more slowly than the ~280-µs average burst duration of the single-molecule measurements (see below)
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