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Since the major enthalpic contribution ΔH* [congruent with] E^sub a^ to the free energy barrier ΔG* = ΔH*-TΔS* for the disk denaturation may arise from the transient disruption of the predominantly hydrophobic protein-lipid interactions, similar values of E^sub a^ may reflect similar combined hydrophobic surfaces in the amphipathic α-helices in apoA-1 and apoA-2 that are comprised of ~50 amino acids in the lipid-bound state of these proteins
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