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. Hydration study of proteins in solution by microwave dielectric analysis
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. Human carbonic anhydrase II is considerably expanded by the interaction of GroEL
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. Given the height scaling used in these measurements, the elongated species are not loosely interacting groups of single particles, but, instead, unified entities
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. DISCUSSION AND CONCLUSIONSWe have discussed a conceptual approach to the protein landscape problem that attempts to remain faithful to the high dimensionality of the system
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. It is worth noting that a multi-event equilibrium unfolding/ dissociation of human GR by GdnHCl has been previously reported (Nordhoff et al
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.4, and the molarity of guanidinium hydrochloride was determined by refractive index as described by Pace (20)
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. Apparently, glycosylation promotes the protein with greater stability, which is considerable in its magnitude (9 kcal/mol)
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. The average shape of a denatured protein is that of a prolate ellipsoid We computed the ensemble-averaged asphericity values for each of the 23 sequences in the EV limit and the resultant data are shown as cross marks in Fig
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.7 for all 23 sequences in the EV limit (Fig
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. Interestingly, although the average shape is independent of sequence in the EV limit, it clearly depends on sequence for folded proteins
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. The helix-loop-helix motif formed by the α-helix 9-α-helix 10 shows intermonomer salt bridges: Asp^sup 540^ in the motif with Arg^sup 422^' in α-helix 5 from the other monomer (the prime is used to designate residues in the other monomer)
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. For a molecule existing in two different states but with similar atom-positional fluctuations, similar configurational entropies are expected for the two states
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. The materials research reported here contributes to the first steps towards commercial xerographic printing of textiles
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. We note that the term "compact" is used in this article to denote the proximity of arms A and B, as described by the FRET efficiency for the current labeling scheme
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.The study associated diclofenac with more than two dozen bird deaths and carprofen and flunixin with several deaths each, Cuthbert and his colleagues report in an analysis now online for Biology Letters
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.Generics growth faces slowdown as fewer drugs are set to lose patentsSAN DIEGO -- Generics are holding their own in the marketplace and increasingly gaining traction over branded pharmaceuticals, despite signs showing an imminent slowdown in growth as fewer drugs come off patent
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